Nerve growth factor (NGF) is a neurotrophic factor involved in pain sensitization22 and associated with chronic pain conditions20. Elevated NGF levels have been found in the cerebrospinal fluid of patients with chronic headache and fibromyalgia25, and linked to increased pain intensity in patients with an inflammatory condition22. An early study in healthy volunteers and patients assessing the therapeutic potential of NGF showed that the dose-limiting effect of NGF was pain and hyperalgesia at the site of injection2.
from The Journal of Pain https://ift.tt/2RpGFI0
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