Low back pain (LBP) is the leading cause of disability worldwide26, yet up to 90% of patients are diagnosed with non-specific LBP, meaning the pathoanatomical source is unclear10. Further, recurrence following an acute episode may be up to 80%25, with little understanding as to why some patients develop ongoing symptoms9. There has recently been increasing focus on alterations in pro-nociceptive and anti-nociceptive mechanisms, purported to explain or contribute to pain exacerbation and persistence across a range of acute to chronic pain conditions34,45,72.
from The Journal of Pain https://ift.tt/2QB3etf
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