Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitive-emotional components mediated by different mechanisms and is processed in a neural network. 6, 26, 37 The persistence of pain is highly related to the strengthening of synaptic transmission on the pain conduction pathway.28 After various painful stimuli, the enhancement of the excitatory synaptic transmission was observed in many areas including the spinal cord,22 the amygdala,3 the hippocampal formation,54 and the anterior cingulate cortex (ACC).
from The Journal of Pain http://bit.ly/2SEdbdj
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