Small fiber neuropathy (SFN) is a condition in which the thinly myelinated Aδ- and unmyelinated C-fibers are affected. The clinical picture is dominated by neuropathic pain, but other sensory symptoms and autonomic complaints may also be present.19 SFN is not a rare disorder, but has mainly been underdiagnosed. There is a conservative minimum incidence estimation of 12/100,000 per year, and a minimum prevalence of 53/100,000.25 The diagnosis SFN is based on the clinical picture in combination with an abnormal intraepidermal nerve fiber density (IENFD) in skin biopsy, and/or abnormal temperature thresholds levels in quantitative sensory testing (QST).
from The Journal of Pain https://ift.tt/2QmEadd
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