Tuesday, November 27, 2018

Alleviation of mechanical allodynia by 14,15-EET in a central post-stroke pain model: possible role of allopregnanolone and δGABAAR

Central post-stroke pain (CPSP) is a neuropathic pain syndrome arising after lesion of the central nervous system (CNS) due to cerebrovascular insult. This syndrome is characterised by somatosensory abnormalities including spontaneous pain, hyperalgesia and allodynia, which localized to body areas corresponding to the injured brain region.2 These conditions are constant and could impair activities of daily living, consequently undermine quality of life and rehabilitation process. However, CPSP is probably the least recognized complication of stroke and the mechanism of which has not been adequately studied to date.

from The Journal of Pain https://ift.tt/2QjSXVf
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