Endomorphins (EMs) are widely considered to be the endogenous ligands for the mu-opioid receptor (MOR), the predominant opioid receptor mediating antinociception. Central administration of EM1 (Tyr-Pro-Trp-Phe-NH2) and EM2 (Tyr-Pro-Phe-Phe-NH2) produce potent MOR-mediated antinociception.57,60,70 We previously reported that the magnitude of antinociception elicited by the spinal application of EM2, varies across the rat estrous cycle, minimal during diestrus but robust, comparable to that of male rats, during proestrus.
from The Journal of Pain https://ift.tt/2Pl8jbm
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