Nonlinear Inverted-U Shaped Relationship between Aging and Epidermal Innervation in the Rat Plantar Hind Paw: a Laser Scanning Confocal Microscopy Study

• Laser-scanning microscopy is used for quantification of rat epidermal nerves• Advanced age is associated with decreased density of epidermal nerves• Middle-aged rats have increased epidermal nerves.• An inverted-U shaped relationship between aging and epidermal nerve density• Epidermal nerve density is not correlated with paw withdrawal thresholds

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