A craniofacial-specific monosynaptic circuit enables heightened affective pain

A craniofacial-specific monosynaptic circuit enables heightened affective pain

A craniofacial-specific monosynaptic circuit enables heightened affective pain, Published online: 13 November 2017; doi:10.1038/s41593-017-0012-1

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The authors show that unlike body sensory neurons, craniofacial nociceptive neurons directly synapse with noxious-stimulus-activated lateral parabrachial neurons (PB_L), which in turn project to multiple limbic centers processing emotions and affects. This monosynaptic pathway is both sufficient and necessary for craniofacial-pain-activated aversive behaviors.

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