VIP cortical conductors set the tone for chronic pain

Nature Neuroscience 20, 1037 (2017). doi:10.1038/nn.4609

Authors: Erika K Harding & Michael W Salter

Loss of inhibition in a circuit in the primary somatosensory cortex that controls the activity of layer 5 neurons drives pain hypersensitivity. Restoring this inhibition resets the inhibitory–excitatory balance, producing analgesia.

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