Synovitis is a key factor in joint diseases pathophysiology, which affects a greater proportion of women than men. P2X7 receptor activation contributes to arthritis, but whether it plays a role in articular inflammatory pain in a sex-dependent manner is unknown. We investigated whether the P2X7 receptor blockade in the knee joint of male and female rats reduces the articular hyperalgesia and inflammation induced by carrageenan knee joint synovitis model. Articular hyperalgesia was quantified using the rat knee joint incapacitation test and the knee joint inflammation, characterized by the concentration of cytokines TNF-α, IL-1β, IL-6 and CINC-1 and by neutrophil migration, was quantified by ELISA and by myeloperoxidase enzyme activity measurement, respectively.
from The Journal of Pain http://ift.tt/2fhzNg0
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