The prevalence of chronic pain rises with increasing age. It has been suggested that the mechanisms responsible for the development of chronic pain overlap with mechanisms involved in aging, potentially implicating age-related changes in descending modulatory pathways. This observation raises the question whether other forms of endogenous pain modulation, in particular placebo analgesia, become compromised with age. Given the known contribution of placebo effects to analgesic treatment outcomes this question is of important clinical relevance.
from The Journal of Pain http://ift.tt/2coMxA1
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