Compelling evidence has shown chronic widespread and exaggerated pain experience in chronic musculoskeletal pain (MSKP) conditions. In addition, neuroimaging research has revealed both morphological and functional brain alterations in these patients. It is hypothesized that brain alterations play a role in the persistent pain complaints of patients with chronic MSKP. Nevertheless, lack of overview exists regarding the relations between brain alterations and clinical measures of pain.The present systematic review was performed according to the PRISMA guidelines, to investigate the relations between structural or functional brain alterations, utilizing magnetic resonance imaging (MRI) scans, and clinical pain measures in patients with chronic MSKP.
from The Journal of Pain http://ift.tt/1XmehqF
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