High inter-individual variability in postoperative opioid consumption is related to genetic and environmental factors. We tested the association between morphine consumption, postoperative pain and single nucleotide polymorphisms (SNPs) within OPRM1, COMT, UGT2B7, and ESR1 gene loci to elucidate genetic prediction of opioid consumption.We analyzed 20 SNPs in 201 unrelated Caucasian patients undergone abdominal surgery receiving postoperative patient-controlled analgesia-administered morphine. Morphine consumption and pain intensity were dependent variables; age and sex covariates.
from The Journal of Pain http://ift.tt/1oSDwSg
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