Aconitine and its structurally-related diterpenoid alkaloids have been shown to interact differentially with neuronal voltage-dependent sodium channels, which was suggested to be responsible for their analgesia and toxicity. Bulleyaconitine A (BAA or BLA) is an aconitine analog and has been prescribed for the management of pain. The present study aimed to evaluate the inhibitory effects of BAA on pain hypersensitivity and morphine anti-nociceptive tolerance, and explore whether the expression of dynorphin A in spinal microglia was responsible for its actions.
from The Journal of Pain http://ift.tt/22HLDAT
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