Inflammatory Bowel Disease (IBD) is a debilitating condition characterized by diarrhea, pain, and weight loss7. It is a lifelong condition that often begins between the ages of 15 and 30. The primary focus of treatment is to reduce inflammation either by administering corticosteroids or immunosuppressants. Treatments targeting pain are limited because standard pain treatments such as non-steroidal anti-inflammatory drugs (NSAIDs) and opioids have negative effects on the gastrointestinal tract. The use of animal models of IBD, such as intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS)2,22 have been developed to better understand the underlying mechanisms and test new treatments.
from The Journal of Pain https://ift.tt/3ldCKhp
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