Longitudinal transcriptomic profiling in carrageenan-induced rat hind paw peripheral inflammation and hyperalgesia reveals progressive recruitment of innate immune system components.

Pain is a common yet complex and potentially debilitating symptom that can negatively influence the quality of life for patients with acute and chronic medical conditions.56 In the United States, approximately 100 million adults are affected by chronic pain at a total medical cost of approximately $600 billion in 2010.13 Providing appropriate pain management with accurate pain assessment in the early phases of tissue injury is essential. However, difficulties in accurately assessing pain can be encountered due to complexities associated with the etiology of the original insult and the neural mechanisms of nociception that are activated.

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