Analgesic Effects of Topical Amitriptyline in Patients with Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights from Studies in Mice

Antidepressants are an essential component of the therapeutic strategy for treatment of many causes of persistent pain 15, 49. Tricyclic antidepressants (TCAs) are the recommended first-line treatment for many forms of persistent neuropathic pain 11, 15, 22. Amitriptyline hydrochloride (amitriptyline), a TCA approved for the treatment of major depression, has been shown to be effective for the treatment of pain associated with a range of neuropathic pain conditions, including diabetic neuropathy, fibromyalgia and postherpetic neuralgia 19, 25, 27.

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