Pain is a significant contributor to a poor quality of life for many patients. Acute pain, typically lasting less than three months, is inadequately managed in over 40% of patients13,30. Chronic pain, which persists for greater than three months following the initial tissue damage, is estimated to have a prevalence over 60%30,51. Long-term use of pharmacologic agents in patients with chronic pain presents additional challenges, including opioid tolerance and treatment failure of anti-depressant medications31,64.
from The Journal of Pain https://ift.tt/3i8shBF
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