Increased CSF levels of apolipoproteins and complement factors in trigeminal neuralgia patients – in depth proteomic analysis using mass spectrometry

Trigeminal neuralgia (TN) is an extremely painful neurological disorder, characterized by short-lasting stabbing facial pain within the distribution of one or more branches of the trigeminal nerve 29. It affects females more than men (ratio 1:1.5) and the prevalence varies between 0.07 – 0.3% 24, 27. Neuroimaging- and cadaver studies imply that the disease is mainly caused by a neurovascular conflict (NVC) at the root entry zone (REZ) of the trigeminal nerve, however, this does not seem to be the only etiology 48.

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