Long term effects of repeated injections of local anesthetic with or without corticosteroid for lumbar spinal stenosis: a randomized trial

Examining affective-motivational dynamics and behavioural implications within the interpersonal context of pain

Emotional, motivational, and interpersonal dimensions are considered integral to pain experience but have largely been examined separately. In this focus article, we argue that an integrative theoretical account that acknowledges each of these elements is a critical next step to capture the complexity and nuance of interpersonal pain dynamics and to shape future research. The aim of this focus article is to provide a foundation for such an account by drawing upon established insights from appraisal theory of emotion, influential behavioral models, empathy/interpersonal pain research, and social psychology literature to highlight conceptual relationships, potential mechanisms of action, and avenues of inquiry that have not previously been examined in the context of pain.

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Minocycline prevents muscular pain hypersensitivity and cutaneous allodynia produced by repeated intramuscular injections of hypertonic saline in healthy human participants

Minocycline, a glial suppressor, prevents behavioural hypersensitivities in animal models of peripheral nerve injury. However clinical trials of minocycline in human studies have produced mixed results. This study addressed two questions: can repeated injections of hypertonic saline (HS) in humans induce persistent hypersensitivity? Can pre-treatment with minocycline, a tetracycline antibiotic with microglial inhibitory effects, prevent the onset of hypersensitivity? Twenty seven healthy participants took part in this double-blind, placebo-controlled study, consisting of six test sessions across 2 weeks.

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Preliminary Investigation of Pain-related Changes in Cerebral Blood Volume in Patients with Phantom Limb Pain

Reply to the Letter to the Editor Regarding 'Clinical assessment of subacromial shoulder impingement - Which factors differ from the asymptomatic population?'

Thank you for your comments regarding the recent publication ‘Clinical Assessment of Subacromial Shoulder Impingement – Which Factors Differ from the Asymptomatic Population?’ Not surprisingly, impingement is a term which does not reflect the underlying cause of all shoulder pain. Hence there is healthy debate, especially amongst physical therapists, regarding alternate terminology (Braman, Zhao, Lawrence, Harrison, & Ludewig, 2013; J. S. Lewis, 2011; McFarland et al., 2013). However, it continues to be a term used throughout the medical literature and in an attempt to embrace this wider audience, until there is agreement about terminology, it was chosen for use in this paper.

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[Perspectives] Illness as a philosophical tool

When once I was bed-bound with back pain, I reached for the words of another invalid, Marcel Proust, and began to make headway with his experience of “lost time”. Recovering 6 months later, I had not come to the end of Remembrance of Things Past, but I had learned that the minutiae of everyday lived experience can have their own fascination (even if Proust never quite addressed his own asthma directly). This approach to life resonates with philosopher Havi Carel's book Phenomenology of Illness. Carel laments that philosophers, traditionally men, neglect a high proportion of what matters to people—love, family, children, ageing, and illness.

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Abdominal pain after surgery

A 24 year old woman presented with acute upper right abdominal pain radiating to the ipsilateral shoulder tip. She had undergone a laparoscopic cholecystectomy four days earlier without immediate...

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