Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature, Published online: 08 September 2021; doi:10.1038/s41586-021-03897-2

MIPS521, a positive allosteric modulator of the adenosine A1 receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

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