Chronic pain adversely affects cognitive performance and significantly impacts quality of life 58,63. Chronic pain patients frequently experience poor memory and concentration, often accompanied by increased anxiety and depression 3,8,14,15,23,35–37,40,57,64,66–68,74,75,82,85,90,102. The hippocampal formation consists of anatomically and functionally distinct subfields including the subiculum, Cornu Ammonis (CA1 – CA4), and dentate gyrus (DG). These subcortical regions play a significant role in memory formation 51, emotional processing, and stress modulation 103.
from The Journal of Pain https://ift.tt/3fHLvyJ
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