Musculoskeletal pain is associated with substantial disability and a large financial burden worldwide49,71,5,70. For example, the total yearly costs of musculoskeletal pain in Australia is estimated at $55 billion4, while in Europe, the yearly costs of back pain are estimated as high as €300 billion 71. Low back and neck pain are among the most prevalent and disabling musculoskeletal conditions70 (global point-prevalence of 9.4%27 and 4.9%28, respectively), however, approximately one in ten individuals (during their life) will experience chronic musculoskeletal pain in multiple body areas73,50,3 and report even greater disability22,14.
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