Migraine is a complex and multifaceted brain disorder, and its clinical manifestations are moderate to severe intensity headaches in combination with nausea, vomiting, and hypersensitivities to visual, auditory, olfactory and somatosensory stimuli 13, 15. This disorder has caused a huge public health burden 9. However, the exact neurological mechanisms contributing to this complex disorder remain unclear. The brainstem has been discussed as the main contributor to the pathogenesis of migraine1, 27.
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