A neural circuit for comorbid depressive symptoms in chronic pain

Nature Neuroscience, Published online: 26 August 2019; doi:10.1038/s41593-019-0468-2

Zhou et al. report a novel 5-HT circuit from the dorsal raphe nucleus to somatostatin-expressing neurons in the central nucleus of the amygdala that partially mediates depressive-like behavior in a mouse model of chronic pain.

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