Implantable motor cortex stimulation (iMCS) to alleviate intractable pain was first described in the 1990s by Tsubokawa and colleagues.64,65 Since then, a total of 700 cases have been described worldwide and an unpredictable, often not long-lasting effect has been reported. Only a small number of studies investigated outcome prediction factors in iMCS treatment of intractable pain. Non-responders, on the other hand, have been far less studied over the years and therefore, little is known about their specific characteristics and underlying pain mechanisms.
from The Journal of Pain http://bit.ly/2SvtJF8
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