Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

• Neonatal handling (NH) markedly reduces stress-induced muscle pain in adult male rats• NH has minimal effect on stress-induced muscle pain in adult females• Gonadectomy blocks the NH effect on stress-induced pain in males• Knockdown of the androgen receptor attenuates NH protection in gonad intact males• Resilience to stress-induced muscle pain by NH is androgen-dependent

from The Journal of Pain http://ift.tt/2H2r4JO
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