Abstract
Background
Associations between inflammatory conditions and low back pain (LBP) have been found frequently in older populations. However, the nature of these relationships in younger populations is unknown. This study aimed to investigate associations between early life chronic or recurrent inflammatory conditions and impactful LBP in adolescence and young adulthood.
Methods
In this longitudinal study we used data from the Raine Study Gen2 participants at the 1,2,3,5,8,10,14,17,20, and 22‐year follow‐ups (N=2868). Data were collected on inflammatory conditions from one to 22‐years of age and occurrences of impactful LBP from 14 to 22‐years of age. Longitudinal and cross‐sectional associations between inflammatory conditions and impactful LBP occurrence were examined. Potential dose response relationships between the number of inflammatory conditions and impactful LBP were also assessed. Logistic regression models were used in the analysis.
Results
Participants with respiratory or atopic conditions during childhood had increased odds of future impactful LBP in adolescence and young adulthood (odds ratio(OR)[95% confidence interval (CI)] = 1.29[1.07, 1.54], 1.23[1.02, 1.49] respectively). There were cross‐sectional associations between inflammatory conditions including respiratory, skin, musculoskeletal, autoimmune, and atopic conditions, with impactful LBP. Participants with two illnesses and three or more illnesses had an increased odds (OR[95% CI] = 1.68[1.30, 2.18]) and (OR[95% CI] = 2.12[1.54, 2.89]) respectively of reporting impactful LBP.
Conclusions
Overall, longitudinal and cross‐sectional associations of respiratory and atopic conditions with impactful LBP in adolescence and young adulthood were identified. More evidence is needed to determine if there is a causal relationship between chronic inflammatory conditions and impactful LBP.
from Wiley: European Journal of Pain: Table of Contents https://ift.tt/37sjJBl
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