Circuit dissection of the role of somatostatin in itch and pain

Circuit dissection of the role of somatostatin in itch and pain

Circuit dissection of the role of somatostatin in itch and pain, Published online: 19 March 2018; doi:10.1038/s41593-018-0119-z

Huang et al. demonstrate that somatostatin (Sst)-expressing primary afferents are pruriceptors. In spinal cord, they show that Sst potentiates itch by disinhibition involving dynorphin-expressing spinal neurons and that Sst also suppresses pain.

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