Assessment of Tapentadol API Abuse Liability with the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System

• Abuse liability of tapentadol API is compared to those of other Scheduled opioids.• Population-level event rates of tapentadol API abuse were lower than comparators.• Drug-availability adjusted event rates of tapentadol abuse were low but not lowest.• Public health burden of tapentadol API appears to be low.

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