Inflammatory Renin-Angiotensin System Disruption Attenuates Sensory Hyperinnervation and Mechanical Hypersensitivity in a Rat Model of Provoked Vestibulodynia

• We developed a tractable rat model of provoked vestibulodynia• The model recapitulates many features of human vestibulodynia• A prominent local inflammatory renin-angiotensin system is present• Blocking AT2 and MrgD receptors prevents hyperinnervation and hypersensitivity• Targeting the renin-angiotensin system may yield effective therapies

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