Kovanur-Sampath and colleagues (Kovanur-Sampath et al., 2017) reviewed the literature on changes in biomarkers following spinal manipulation and called for trials targeting symptomatic populations to validate their findings. This letter describes findings of the OSTEOPATHIC Trial (Licciardone et al., 2013), which was not included in their review. This was a randomized controlled trial of osteopathic manipulative treatment (OMT) vs. sham OMT in 455 patients with chronic low back pain. It was funded in part by the National Institutes of Health and registered with ClinicalTrials.gov.
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