A common clinical problem with opioid analgesics is the loss of analgesic efficacy after repeated dosing; when this occurs, it is not clear what principles should guide providing effective analgesia among opioid-dependent individuals. This within-subject inpatient study aimed to determine if physically dependent opioid abusers (n=11) experience changes in oxycodone-induced analgesia during two oxycodone maintenance (30mg p.o./q.i.d.) phases: Initial Stabilization (Days 1 – 3) and after 6 weeks of Chronic Dosing.
from The Journal of Pain http://ift.tt/2mciAHJ
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