This 12-week study evaluated the efficacy and safety of capsaicin 8% patch versus placebo patch in painful diabetic peripheral neuropathy (PDPN). Patients aged ≥18 years with PDPN were randomized (1:1) to one 30-minute treatment (capsaicin 8% patch or placebo patch) to painful areas of feet. Overall, 369 patients were randomized (capsaicin 8% patch, n=186; placebo patch, n=183). Percentage reduction in average daily pain score from baseline to between Weeks 2–8 (the primary endpoint) was statistically significant for capsaicin 8% patch versus placebo (-27.4% versus -20.9%; p=0.025); improvements in pain were observed from Week 2 onwards.
from The Journal of Pain http://ift.tt/2e0ULwX
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