Saturday, January 30, 2016
The Pain Experience of Hispanic Americans: A Critical Literature Review and Conceptual Model
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Friday, January 29, 2016
Paraspinous lidocaine injection for chronic nonspecific low back pain: A randomized controlled clinical trial
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Trends in Opioid Dosing Among of Washington State Medicaid Patients Before and After Opioid Dosing Guideline Implementation
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Thursday, January 28, 2016
Corrigendum to “Development and psychometric evaluation of the Musculoskeletal Pain Intensity and Interference Questionnaire for professional orchestra Musicians” [Manual Therapy 19 (6) (2014) 575–588]
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Opioid Prescribing for Chronic Pain — Achieving the Right Balance through Education
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Wednesday, January 27, 2016
Psychiatrist is charged after 12 patient deaths
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Sunday, January 24, 2016
Friday, January 22, 2016
Herbal Medicine for Low Back Pain: A Cochrane Review
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Glycosaminoglycan Chemical Exchange Saturation Transfer of Lumbar Intervertebral Discs in Healthy Volunteers
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Is There an Association Between Radiological Severity of Lumbar Spinal Stenosis and Disability, Pain, or Surgical Outcome?: A Multicenter Observational Study
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Mechanism of Action of Spinal Mobilizations: A Systematic Review
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Minimally Invasive Versus Open Laminectomy for Lumbar Stenosis: A Systematic Review and Meta-Analysis
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Complications and Rates of Subsequent Lumbar Surgery Following Lumbar Total Disc Arthroplasty and Lumbar Fusion
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Wednesday, January 20, 2016
Worms in the emergency department
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Tuesday, January 19, 2016
Ultrasound measurement of deep and superficial abdominal muscles thickness during standing postural tasks in participants with and without chronic low back pain
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Monday, January 18, 2016
Margaret McCartney: Regulation doesn’t guarantee safety
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Saturday, January 16, 2016
Friday, January 15, 2016
Causal effects of threat and challenge appraisals on coping and pain perception
Abstract
Background
Numerous studies have found appraisals of pain as a source of potential threat or tissue damage influence pain perception and coping. Conversely, causal effects of challenge appraisals reflecting potential future benefits of bearing pain have received little attention. This experiment was designed to elucidate effects of appraising laboratory pain as a source of potential threat and challenge on pain perception and coping.
Methods
Before engaging in a cold pressor test (CPT), young adult women (N = 112) and men (N = 49) were randomly assigned to one of three conditions: a higher threat group in which participants read an orienting passage describing symptoms and consequences of frostbite (pain as a signal for nociception), a lower threat group in which participants read about CPT safety (pain independent of nociception) or a challenge appraisal group in which participants read a passage describing how persistence in the face of discomfort predicts future life success and satisfaction.
Results
The higher threat group had lower pain tolerance and catastrophized more during the task than lower threat and challenge appraisal groups. Conversely, the challenge appraisal group reported using more cognitive strategies (ignoring, diverting attention, coping self-statements) in managing pain than either threat group. Structural equation modelling indicated paths of subjective threat and challenge appraisals with pain tolerance were fully mediated by individual differences in reported cognitive coping and/or pain catastrophizing.
Conclusions
Findings underscore causal effects of pain appraisals on coping responses and pain perception.
What does this study add?
Effects of challenge appraisals of pain as a source of potential future growth or development have not been considered in experimental pain research.
Causal effects of primary appraisals of laboratory pain as a source of potential threat and challenge were elucidated in relation to pain perception and coping.
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Individual and joint effects of risk factors for onset widespread pain and obesity – a population-based prospective cohort study
Abstract
Background
Widespread musculoskeletal pain (WSP) and obesity frequently co-occur and may have shared risk factors. We aimed to investigate whether four dichotomized risk factors individually or jointly increase the risk for the onset of WSP and onset of obesity.
Methods
Persons aged 34–76 years in 2004 living in Ullensaker municipality, Norway, responded to questionnaires in 2004 and 2010 (n = 1553). Using causal interaction analyses, we examined whether baseline obesity and WSP, poor sleep quality, mental distress and poor physical fitness jointly increased the risk of new onset WSP (≥3 pain sites leading to disability the last year) and new onset obesity (self-reported BMI ≥30 kg/m2) in persons without WSP (n = 1270) or without obesity (n = 1300) at baseline respectively.
Results
The mean (SD) age was 51 (12.1) years and 56% were female. The incidence of WSP and obesity were 9.1% and 5.4%. Mental distress and poor sleep quality individually and jointly with poor physical fitness increased WSP onset risk (relative excess risk due to interaction [RERI] = 1.90, 95% CI, 0.39–3.42 and RERI = 1.43, 95% CI, 0.10–2.76). Poor physical fitness individually increased the risk for new onset obesity, and baseline WSP and poor sleep quality jointly (RERI = 1.87, 95% CI, 0.49–3.24). The presence of more risk factors was dose-dependently associated with onset WSP and to a lesser extent with onset obesity.
Conclusion
The onset of WSP and the onset of obesity were results of joint effects of exposures. Poor physical fitness was a key covariate in increasing the risk for both conditions.
What does this study add?
In a general population, the new onset of widespread pain and new onset of obesity were results of joint effects of risk factors and particularly poor physical fitness.
The study may aid in the identification of patients at risk of future disability.
from European Journal of Pain http://ift.tt/1PwqlfM
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Altered fMRI resting-state connectivity in individuals with fibromyalgia on acute pain stimulation
Abstract
Background
Fibromyalgia is a chronic widespread pain condition, with patients commonly reporting other symptoms such as sleep difficulties, memory complaints and fatigue. The use of magnetic resonance imaging (MRI) in fibromyalgia has allowed for the detection of neural abnormalities, with alterations in brain activation elicited by experimental pain and alterations in resting state connectivity related to clinical pain.
Methods
In this study, we sought to monitor state changes in resting brain connectivity following experimental pressure pain in fibromyalgia patients and healthy controls. Twelve fibromyalgia patients and 15 healthy controls were studied by applying discrete pressure stimuli to the thumbnail bed during MRI. Resting-state functional MRI scanning was performed before and immediately following experimental pressure pain. We investigated changes in functional connectivity to the thalamus and the insular cortex.
Results
Acute pressure pain increased insula connectivity to the anterior cingulate and the hippocampus. Additionally, we observed increased thalamic connectivity to the precuneus/posterior cingulate cortex, a known part of the default mode network, in patients but not in controls. This connectivity was correlated with changes in clinical pain.
Conclusions
These data reporting changes in resting-state brain activity following a noxious stimulus suggest that the acute painful stimuli may contribute to the alteration of the neural signature of chronic pain.
What does this study/add?
In this study acute pain application shows an echo in functional connectivity and clinical pain changes in chronic pain.
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Thursday, January 14, 2016
[Correspondence] Methadone for prisoners – Authors' reply
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Wednesday, January 13, 2016
Lean mass predicts conditioned pain modulation in adolescents across weight status
Abstract
Background
There is a wide continuum of conditioned pain modulation (CPM) in adults with older adults experiencing an attenuated CPM response compared with younger adults. Less is known for adolescents and the role of anthropometrics.
Methods
Fifty-six adolescents (15.1 ± 1.8 years; 32 normal weight and 24 overweight/obese; 27 boys) completed in a CPM session that included anthropometric testing. Pressure pain thresholds were measured at the nailbed and deltoid muscle (test stimuli) with the foot submerged in a cool or ice water bath (conditioning stimulus). Weight status, body composition (Dual-energy X-ray absorptiometry scan), physical activity levels and clinical pain were also evaluated.
Results
The CPM response in adolescents was similar across sites (nailbed vs. deltoid), weight status (normal vs. overweight/obese) and sex. CPM measured at the deltoid muscle was positively associated with left arm lean mass but not fat mass; lean mass of the arm uniquely predicted 10% of the CPM magnitude. CPM measured at the nailbed was positively correlated with physical activity levels.
Conclusions
These results suggest that lean mass and physical activity levels may contribute to endogenous pain inhibition in adolescents across weight status.
from European Journal of Pain http://ift.tt/1Zw9wfr
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Social environment alters opioid-induced hyperalgesia and antinociceptive tolerance in adolescent mice
Abstract
Background
Chronic opioid treatment is complicated by the development of tolerance and hyperalgesia. Social environment alters both opioid-induced behaviours and nociceptive mechanisms. Our previous studies demonstrated that, in adolescent rodents, the susceptibility to acquire opioid dependence and reward is dependent on the nature of social housing conditions. Specifically, our previous studies demonstrate that housing morphine-treated mice with drug-naïve animals mitigates the abuse liability of opioids. Thus, this study tested the effect of social housing conditions on the development of adaptive processes to morphine antinociception.
Method
Adolescent males were group-housed in different conditions. In the mixed treatment condition, mice treated with 20 mg/kg morphine (i.e. ‘morphine cage-mates’) and saline (i.e. ‘saline cage-mates’) were housed together. In the separated treatment conditions, all mice in the cage received morphine (i.e. ‘morphine only’) or saline (i.e. ‘saline only’). All animals were tested for baseline pain sensitivity and for the response to morphine in the tail withdrawal, hot plate, acetone and von Frey filament tests, during and after discontinuation of opioid treatment.
Results
Both morphine cage-mate and morphine only animals developed antinociceptive tolerance. However, this effect was more robust and persistent in the morphine only group. Notably, morphine only animals, but not morphine cage-mates, developed opioid-induced hyperalgesia.
Conclusion
This study demonstrates that housing morphine-treated mice with drug-naïve animals mitigates the development of opioid-induced hyperalgesia and antinociceptive tolerance. Thus, this study indicates that social environment influences the effectiveness of opioid pain management.
from European Journal of Pain http://ift.tt/1PZepFX
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Robot-guided neuronavigated rTMS as an alternative therapy for central (neuropathic) pain: Clinical experience and long-term follow-up
Abstract
Background
Repetitive transcranial magnetic stimulation (rTMS) appears as a useful tool to alleviate neuropathic pain but only few data are available for the long-term benefit of this treatment.
Methods
Here we report the effects of rTMS sessions, considered as a possible therapy for pain relief after a failure of different medications in patients with central (neuropathic) pain. We review here the prospectively collected data of the first forty patients treated as follow: 20 Hz stimulation delivered over the contralateral primary motor cortex (M1), each 3–4 weeks.
Results
A total of 440 rTMS sessions was collected (mean sessions number: 11, range: 1–37, follow-up 312 days on average, maximum 2.8 years). After four sessions, nine patients (22.5%) discontinued rTMS because of a lack of efficiency (<10% pain-relief). The other 31 patients (77.5%) had a cumulative effect across sessions leading to a mean pain relief of 41% for a duration of 15.6 days. A correlation was observed between pain relief in the first session and long-term pain relief (R = 0.649. p = 5.6*10−6). Both intensity and duration of pain relief were significantly better for patients with persistent laser evoked potentials (LEPs, p = 0.049 and 0.0018). We did not observe any adverse-effects.
Conclusion
These results suggest that repeated sessions of 20 Hz rTMS over M1 are interesting in clinical practice for the treatment of selected patients with central pain. Both the cumulative effects across the first sessions and the long duration of pain-relief should impact further randomized trials that are warranted to conclude formally on rTMS efficiency in central pain.
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Tuesday, January 12, 2016
Differences in pain coping between Black and White Americans: A meta-analysis
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Bilateral absent uterine arteries
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Saturday, January 9, 2016
Feasibility of the subgroup criteria included in the treatment-strategy-based classification system for patients with non-specific low back pain
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An investigation into the effects of applying a lumbar Maitland mobilisation at different frequencies on sympathetic nervous system activity levels in the lower limb
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Friday, January 8, 2016
Targeted exercise for muscles that support the spine reduces low back pain, Cochrane review shows
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